Article
Clinical implications of nonsarcomeric gene polymorphisms in hypertrophic cardiomyopathy.
European journal of clinical investigation - 1 Feb 2016
García-Honrubia Antonio, Hernández-Romero Diana, Orenes-Piñero Esteban, Romero-Aniorte Ana Isabel, Climent Vicente, García Miriam, Garrigos-Gómez Noemí, Moro Concepción, Valdés Mariano, Marín Francisco
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by cardiomyocyte hypertrophy and fibrosis. Although is an autosomal dominant trait, a group of nonsarcomeric genes have been postulated as modifiers of the phenotypic heterogeneity. MATERIAL AND METHODS: We prospectively recruited 168 HCM patients and 136 healthy controls from three referral centres. Patients and controls were clinically stable at...
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