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Article

An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period.

G3 (Bethesda, Md.) - 23 Nov 2015

Ray Surjyendu, Tzeng Ruei-Ying, DiCarlo Lisa M, Bundy Joseph L, Vied Cynthia, Tyson Gary, Nowakowski Richard, Arbeitman Michelle N

Abstract excerpt

The developmental transition to motherhood requires gene expression changes that alter the brain to drive the female to perform maternal behaviors. We broadly examined the global transcriptional response in the mouse maternal brain, by examining four brain regions: hypothalamus, hippocampus, neocortex, and cerebellum, in virgin females, two pregnancy time points, and three postpartum time points. We find that...

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Identifiers

PMID: 26596646
DOI: 10.1534/g3.115.020982
PMCID: PMC4704721

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