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Epstein-Barr Virus MicroRNA miR-BART20-5p Suppresses Lytic Induction by Inhibiting <i>BAD</i> -Mediated <i>caspase-3</i> -Dependent Apoptosis

19 Nov 2015

Abstract excerpt

UNLABELLED: Epstein-Barr virus (EBV) is a human gammaherpesvirus associated with a variety of tumor types. EBV can establish latency or undergo lytic replication in host cells. In general, EBV remains latent in tumors and expresses a limited repertoire of latent proteins to avoid host immune surveillance. When the lytic cycle is triggered by some as-yet-unknown form of stimulation, lytic gene expression and...

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PMID: 26581978
DOI: 10.1128/jvi.02794-15

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