Article
Evaluation of the linkage-disequilibrium method for the estimation of effective population size when generations overlap: an empirical case.
BMC genomics - 11 Nov 2015
Saura María, Tenesa Albert, Woolliams John A, Fernández Almudena, Villanueva Beatriz
Abstract excerpt
BACKGROUND: Within the genetic methods for estimating effective population size (N e ), the method based on linkage disequilibrium (LD) has advantages over other methods, although its accuracy when applied to populations with overlapping generations is a matter of controversy. It is also unclear the best way to account for mutation and sample size when this method is implemented. Here we have addressed the...
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