Article
Dermal Fibroblasts from the Red Duroc Pig Have an Inherently Fibrogenic Phenotype: An In Vitro Model of Fibroproliferative Scarring.
Plastic and reconstructive surgery - 1 Nov 2015
Sood Ravi F, Muffley Lara A, Seaton Max E, Ga Maricar, Sirimahachaiyakul Pornthep, Hocking Anne M, Gibran Nicole S
Abstract excerpt
BACKGROUND: The pathophysiology of hypertrophic scarring is unknown in part because of the lack of a robust animal model. Although the red Duroc pig has emerged as a promising in vivo model, the cellular mechanisms underlying Duroc scarring are unknown, and the size and cost of Duroc pigs are obstacles to their use. Given the central role of the dermal fibroblast in scarring, the authors hypothesized that dermal...
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