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Article

Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma.

Digestive diseases and sciences - 1 Feb 2016

Smith Eric, Palethorpe Helen M, Ruszkiewicz Andrew R, Edwards Suzanne, Leach Damien A, Underwood Tim J, Need Eleanor F, Drew Paul A

Abstract excerpt

BACKGROUND: Esophageal adenocarcinoma is a male-dominant disease, but the role of androgens is unclear. AIMS: To examine the expression and clinical correlates of the androgen receptor (AR) and the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma. METHODS: Expression of AR and FKBP5 was determined by immunohistochemistry. The effect of the AR ligand 5α-dihydrotestosterone...

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Topics

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Genetic Predisposition to Disease

Share to Prognosis

Share to Receptors, Androgen

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Source

Identifiers

PMID: 26467701
DOI: 10.1007/s10620-015-3909-0

Genes

FKBP5
FBXO32
HMOX1
KLK3
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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