Article
The Cannabinoid Receptor 2 Q63R Variant Modulates the Relationship between Childhood Obesity and Age at Menarche.
PloS one - 1 Jan 2015
Bellini Giulia, Grandone Anna, Torella Marco, Miraglia del Giudice Emanuele, Nobili Bruno, Perrone Laura, Maione Sabatino, Rossi Francesca
Abstract excerpt
BACKGROUND: The ovary is an important site where gene variants modulate pubertal timing. The cannabinoid receptor 2 (CB2) is expressed in the ovary, plays a role in folliculogenesis and ovulation, and can be modulated by estrogens. Obesity is strictly associated with early menarche and is characterized by sex hormone and endocannabinoid derangement. AIM: In this study, we investigated the role of the CB2 receptor...
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