Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan.

doi:10.1038/srep14762

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Article

Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan.

Scientific reports - 5 Oct 2015

Lin Ying-Ju, Chang Jeng-Sheng, Liu Xiang, Tsang Hsinyi, Chien Wen-Kuei, Chen Jin-Hua, Hsieh Hsin-Yang, Hsueh Kai-Chung, Shiao Yi-Tzone, Li Ju-Pi, Lin Cheng-Wen, Lai Chih-Ho, Wu Jer-Yuarn, Chen Chien-Hsiun, Lin Jaung-Geng, Lin Ting-Hsu, Liao Chiu-Chu, Huang Shao-Mei, Lan Yu-Ching, Ho Tsung-Jung, Liang Wen-Miin, Yeh Yi-Chun, Lin Jung-Chun, Tsai Fuu-Jen

Abstract excerpt

Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis affecting infants and young children. Coronary artery aneurysm (CAA) formation is the major complication of KD and the leading cause of acquired cardiovascular disease among children. To identify susceptible loci that might predispose patients with KD to CAA formation, a genome-wide association screen was performed in a Taiwanese KD...

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Identifiers

PMID: 26434682
DOI: 10.1038/srep14762
PMCID: PMC4593004

Genes

PLCB1
PLCB4
KCNQ5
PLCL1

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