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Article

Targeting brain metastases in ALK-rearranged non-small-cell lung cancer.

The Lancet. Oncology - 1 Oct 2015

Zhang Isabella, Zaorsky Nicholas G, Palmer Joshua D, Mehra Ranee, Lu Bo

Abstract excerpt

The incidence of brain metastases has increased as a result of improved systemic control and advances in imaging. However, development of novel therapeutics with CNS activity has not advanced at the same rate. Research on molecular markers has revealed many potential targets for antineoplastic agents, and a particularly important aberration is translocation in the ALK gene, identified in non-small-cell lung...

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Share to Anaplastic Lymphoma Kinase
Share to Blood-Brain Barrier
Share to Capillary Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

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Share to Radiotherapy, Adjuvant

Share to Receptor Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 26433824
DOI: 10.1016/S1470-2045(15)00013-3

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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