Article
Early infancy microbial and metabolic alterations affect risk of childhood asthma.
Science translational medicine - 30 Sept 2015
Arrieta Marie-Claire, Stiemsma Leah T, Dimitriu Pedro A, Thorson Lisa, Russell Shannon, Yurist-Doutsch Sophie, Kuzeljevic Boris, Gold Matthew J, Britton Heidi M, Lefebvre Diana L, Subbarao Padmaja, Mandhane Piush, Becker Allan, McNagny Kelly M, Sears Malcolm R, Kollmann Tobias, Mohn William W, Turvey Stuart E, Finlay B Brett
Abstract excerpt
Asthma is the most prevalent pediatric chronic disease and affects more than 300 million people worldwide. Recent evidence in mice has identified a "critical window" early in life where gut microbial changes (dysbiosis) are most influential in experimental asthma. However, current research has yet to establish whether these changes precede or are involved in human asthma. We compared the gut microbiota of 319...
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