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Article

Low load for disruptive mutations in autism genes and their biased transmission.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2015

Iossifov Ivan, Levy Dan, Allen Jeremy, Ye Kenny, Ronemus Michael, Lee Yoon-Ha, Yamrom Boris, Wigler Michael

Abstract excerpt

We previously computed that genes with de novo (DN) likely gene-disruptive (LGD) mutations in children with autism spectrum disorders (ASD) have high vulnerability: disruptive mutations in many of these genes, the vulnerable autism genes, will have a high likelihood of resulting in ASD. Because individuals with ASD have lower fecundity, such mutations in autism genes would be under strong negative selection...

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Identifiers

PMID: 26401017
DOI: 10.1073/pnas.1516376112
PMCID: PMC4611648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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