Article
DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity.
Genetics and molecular research : GMR - 8 Sept 2015
Santos M, Maia L L, Silva C V M, Peterle G T, Mercante A M C, Nunes F D, Carvalho M B, Tajara E H, Louro I D, Silva-Conforti A M A
Abstract excerpt
Death-associated protein 1 (DAP1) is a member of the DAP family. Its expression is associated with cell growth and normal death of the neoplastic cells, regulated by the mammalian target of the rapamycin protein. Activated DAP1 negatively regulates autophagy, which has been associated with the development and progression of several diseases, such as cancer, and with prognosis and survival of diverse tumor types....
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