Article
A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness.
PloS one - 1 Jan 2015
Kondo Mineo, Das Gautami, Imai Ryoetsu, Santana Evelyn, Nakashita Tomio, Imawaka Miho, Ueda Kosuke, Ohtsuka Hirohiko, Sakai Kazuhiko, Aihara Takehiro, Kato Kumiko, Sugimoto Masahiko, Ueno Shinji, Nishizawa Yuji, Aguirre Gustavo D, Miyadera Keiko
Abstract excerpt
Congenital stationary night blindness (CSNB) is a non-progressive, clinically and genetically heterogeneous disease of impaired night vision. We report a naturally-occurring, stationary, autosomal recessive phenotype in beagle dogs with normal daylight vision but absent night vision. Affected dogs had normal retinas on clinical examination, but showed no detectable rod responses. They had "negative-type" mixed...
Topics
- Animals
- Calcium Channels, L-Type
- Disease Models, Animal
- Dogs
- Eye Diseases, Hereditary
- Female
- Gene Expression Regulation
- Genetic Diseases, X-Linked
- Genetic Predisposition to Disease