A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients.

doi:10.18632/oncotarget.4978

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Article

A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients.

Oncotarget - 6 Oct 2015

Cheng Wen, Ren Xiufang, Cai Jinquan, Zhang Chuanbao, Li Mingyang, Wang Kuanyu, Liu Yang, Han Sheng, Wu Anhua

Abstract excerpt

Although O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation status is an important marker for glioblastoma multiforme (GBM), there is considerable variability in the clinical outcome of patients with similar methylation profiles. The present study aimed to refine the prognostic and predictive value of MGMT promoter status in GBM by identifying a micro (mi)RNA risk signature. Data from The Cancer...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Brain Neoplasms
Chi-Square Distribution
Child
China
DNA Methylation
DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Repair Enzymes

Databases, Genetic

Female

Gene Expression Profiling

Genetic Predisposition to Disease

Glioblastoma

Humans

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Open in PubMed Open full text

Identifiers

PMID: 26320189
DOI: 10.18632/oncotarget.4978
PMCID: PMC4745726

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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