Integrating Tumor and Stromal Gene Expression Signatures With Clinical Indices for Survival Stratification of Early-Stage Non–Small Cell Lung Cancer

Abstract excerpt

BACKGROUND: Accurate survival stratification in early-stage non-small cell lung cancer (NSCLC) could inform the use of adjuvant therapy. We developed a clinically implementable mortality risk score incorporating distinct tumor microenvironmental gene expression signatures and clinical variables. METHODS: Gene expression profiles from 1106 nonsquamous NSCLCs were used for generation and internal validation of a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ferroptosis and cancer prognosis
• Share to Lung Cancer Diagnosis and Treatment
• Share to Radiomics and Machine Learning in Medical Imaging