Effects of Interference Between Selected Loci on the Mutation Load, Inbreeding Depression, and Heterosis.

Abstract excerpt

A classical prediction from single-locus models is that inbreeding increases the efficiency of selection against partially recessive deleterious alleles (purging), thereby decreasing the mutation load and level of inbreeding depression. However, previous multilocus simulation studies found that increasing the rate of self-fertilization of individuals may not lead to purging and argued that selective interference...

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