Article
A Year of Infection in the Intensive Care Unit: Prospective Whole Genome Sequencing of Bacterial Clinical Isolates Reveals Cryptic Transmissions and Novel Microbiota.
PLoS genetics - 1 Jul 2015
Roach David J, Burton Joshua N, Lee Choli, Stackhouse Bethany, Butler-Wu Susan M, Cookson Brad T, Shendure Jay, Salipante Stephen J
Abstract excerpt
Bacterial whole genome sequencing holds promise as a disruptive technology in clinical microbiology, but it has not yet been applied systematically or comprehensively within a clinical context. Here, over the course of one year, we performed prospective collection and whole genome sequencing of nearly all bacterial isolates obtained from a tertiary care hospital's intensive care units (ICUs). This unbiased...
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