Article
Trinucleotide Repeat Expansion in the TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy in Japanese.
Investigative ophthalmology & visual science - 1 Jul 2015
Nakano Masakazu, Okumura Naoki, Nakagawa Hiroko, Koizumi Noriko, Ikeda Yoko, Ueno Morio, Yoshii Kengo, Adachi Hiroko, Aleff Ross A, Butz Malinda L, Highsmith W Edward, Tashiro Kei, Wieben Eric D, Kinoshita Shigeru, Baratz Keith H
Abstract excerpt
PURPOSE: The purpose of this study was to evaluate the association between the intronic expansion of a trinucleotide repeat (TNR) in the TCF4 gene and Fuchs' endothelial corneal dystrophy (FECD) in a Japanese population. METHODS: Forty-seven Japanese FECD patients and 96 age-matched controls were recruited. FECD patients and controls were examined by slit-lamp and noncontact specular microscopy. The repeat length...
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