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Article

Role of the IL-6 gene in the etiopathogenesis of idiopathic scoliosis.

Analytical cellular pathology (Amsterdam) - 1 Jan 2015

Nikolova Svetla, Dikova Milka, Dikov Dobrin, Djerov Assen, Dzhebir Gyulnas, Atanasov Ventseslav, Savov Alexey, Kremensky Ivo

Abstract excerpt

Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region of IL-6 gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to...

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Identifiers

PMID: 26199858
DOI: 10.1155/2015/621893
PMCID: PMC4493265

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