Article
Differential impact of consanguineous marriages on autosomal recessive diseases in Tunisia.
American journal of human biology : the official journal of the Human Biology Council - 1 Jan 2000
Ben Halim Nizar, Hsouna Sana, Lasram Khaled, Rejeb Insaf, Walha Asma, Talmoudi Faten, Messai Habib, Sabrine Ben Brick Ahlem, Ouragini Houyem, Cherif Wafa, Nagara Majdi, Ben Rhouma Faten, Chouchene Ibtissem, Ouechtati Farah, Bouyacoub Yosra, Ben Rekaya Mariem, Messaoud Olfa, Ben Ammar Slim, El Matri Leila, Tebib Neji, Ben Dridi Marie F, Mokni Mourad, Amouri Ahlem, Kefi Rym, Abdelhak Sonia
Abstract excerpt
OBJECTIVES: Consanguinity is common in Tunisia. However, little information exists on its impact on recessive disorders. In this study, we evaluate the impact of consanguineous marriages on the occurrence of some specific autosomal recessive disorders and consider how other factors, such as population substructure and mutation frequency, may be of equal importance in disease prevalence. METHODS: Consanguinity...
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