Article
Mutations within the LINC-HELLP non-coding RNA differentially bind ribosomal and RNA splicing complexes and negatively affect trophoblast differentiation.
Human molecular genetics - 1 Oct 2015
van Dijk Marie, Visser Allerdien, Buabeng Kwadwo M L, Poutsma Ankie, van der Schors Roel C, Oudejans Cees B M
Abstract excerpt
LINC-HELLP, showing chromosomal linkage with the pregnancy-specific HELLP syndrome in Dutch families, reduces differentiation from a proliferative to an invasive phenotype of first-trimester extravillous trophoblasts. Here we show that mutations in LINC-HELLP identified in HELLP families negatively affect this trophoblast differentiation either by inducing proliferation rate or by causing cell cycle exit as shown...
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