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Article

Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2015

Jones Karlie, Wei Christina, Schoser Benedikt, Meola Giovanni, Timchenko Nikolai, Timchenko Lubov

Abstract excerpt

Myotonic dystrophies type 1 (DM1) and type 2 (DM2) are neuromuscular diseases, caused by accumulation of CUG and CCUG RNAs in toxic aggregates. Here we report that the increased stability of the mutant RNAs in both types of DM is caused by deficiency of RNA helicase p68. We have identified p68 by studying CCUG-binding proteins associated with degradation of the mutant CCUG repeats. Protein levels of p68 are...

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Identifiers

PMID: 26080402
DOI: 10.1073/pnas.1422273112
PMCID: PMC4491770

Genes

DDX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5.PMID 26080402Read ↗

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