Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.

PLoS genetics - 1 Jun 2015

Wilbe Maria, Kozyrev Sergey V, Farias Fabiana H G, Bremer Hanna D, Hedlund Anna, Pielberg Gerli R, Seppälä Eija H, Gustafson Ulla, Lohi Hannes, Carlborg Örjan, Andersson Göran, Hansson-Hamlin Helene, Lindblad-Toh Kerstin

Abstract excerpt

The complexity of clinical manifestations commonly observed in autoimmune disorders poses a major challenge to genetic studies of such diseases. Systemic lupus erythematosus (SLE) affects humans as well as other mammals, and is characterized by the presence of antinuclear antibodies (ANA) in patients' sera and multiple disparate clinical features. Here we present evidence that particular sub-phenotypes of canine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Cell Adhesion Molecules Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genome

Share to Haplotypes

Share to Lupus Erythematosus, Systemic

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 26057447
DOI: 10.1371/journal.pgen.1005248
PMCID: PMC4461293

Genes

DAPP1
HOMER2
LAMTOR3
PTPN3
VRK1
WFDC3
WHAMM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.PMID 26057447Read ↗

Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical ManifestationsSemantic proximity Read ↗

Multiple autoimmune diseases syndrome in Italian Greyhounds: preliminary studies of genome-wide diversity and possible associations within the dog leukocyte antigen (DLA) complex.Semantic proximity Read ↗

Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs.Semantic proximity Read ↗

Genome-wide differential expression reveals candidate genes involved in the pathogenesis of lupus and lupus nephritis.Semantic proximity Read ↗

Searching for genes in complex diseases: lessons from systemic lupus erythematosus.Semantic proximity Read ↗

MHC class II polymorphism is associated with a canine SLE-related disease complex.Semantic proximity Read ↗

Clinical, serological, and targeted genetic analysis of systemic lupus erythematosus in Kazakhstan.Semantic proximity Read ↗

DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breedsSemantic proximity Read ↗

A newly identified pathology of Episodic Angioedema with Hypereosinophilia (Gleich’s Syndrome) revealed by Multi-Omics AnalysisSemantic proximity Read ↗

Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations.Semantic proximity Read ↗

Expression of Human Endogenous Retroviruses in Systemic Lupus Erythematosus: Multiomic Integration With Gene ExpressionSemantic proximity Read ↗

MHC class II is an important genetic risk factor for canine systemic lupus erythematosus (SLE)-related disease: implications for reproductive success.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.