Article
Phlebotomus papatasi SP15: mRNA expression variability and amino acid sequence polymorphisms of field populations.
Parasites & vectors - 29 May 2015
Ramalho-Ortigão Marcelo, Coutinho-Abreu Iliano V, Balbino Valdir Q, Figueiredo Carlos Alberto S, Mukbel Rami, Dayem Hussan, Hanafi Hanafi A, El-Hossary Shabaan S, Fawaz Emad El-Din Y, Abo-Shehada Mahmoud, Hoel David F, Stayback Gwen, Wadsworth Mariha, Shoue Douglas A, Abrudan Jenica, Lobo Neil F, Mahon Andrew R, Emrich Scott J, Kamhawi Shaden, Collins Frank H, McDowell Mary Ann
Abstract excerpt
BACKGROUND: The Phlebotomus papatasi salivary protein PpSP15 was shown to protect mice against Leishmania major, suggesting that incorporation of salivary molecules in multi-component vaccines may be a viable strategy for anti-Leishmania vaccines. METHODS: Here, we investigated PpSP15 predicted amino acid sequence variability and mRNA profile of P. papatasi field populations from the Middle East. In addition,...
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