Article
Identification and functional characterisation of a novel dopamine beta hydroxylase gene variant associated with attention deficit hyperactivity disorder.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jan 2015
Tong Janette, McKinley Leigh-Anne, Cummins Tarrant D R, Johnson Beth, Matthews Natasha, Vance Alasdair, Heussler Helen, Gill Michael, Kent Lindsey, Bellgrove Mark A, Hawi Ziarih
Abstract excerpt
OBJECTIVES: Dysregulation in neurotransmitter signalling has been implicated in the aetiology of attention deficit hyperactivity disorder (ADHD). Polymorphisms of the gene encoding dopamine beta hydroxylase (DBH) have been reported to be associated with ADHD; however, small sample sizes have led to inconsistency. METHODS: We conducted transmission disequilibrium test analysis in 794 nuclear families to examine...
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