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Article

Effects of etidronate on the Enpp1⁻/⁻ mouse model of generalized arterial calcification of infancy.

International journal of molecular medicine - 1 Jul 2015

Huesa Carmen, Staines Katherine A, Millán Jose Luis, MacRae Vicky E

Abstract excerpt

Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder of spontaneous infantile arterial and periarticular calcification which is attributed to mutations in the ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) gene. Whilst the bisphosphonate, etidronate, is currently used off-label for the treatment for GACI, recent studies have highlighted its detrimental effects on...

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Identifiers

PMID: 25975272
DOI: 10.3892/ijmm.2015.2212
PMCID: PMC4494596

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