Article
SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy.
Oncotarget - 20 May 2015
Mellai Marta, Cattaneo Monica, Storaci Alessandra Maria, Annovazzi Laura, Cassoni Paola, Melcarne Antonio, De Blasio Pasquale, Schiffer Davide, Biunno Ida
Abstract excerpt
The suppressor of Lin-12-like (C. elegans) (SEL1L) is involved in the endoplasmic reticulum (ER)-associated degradation pathway, malignant transformation and stem cells. In 412 formalin-fixed and paraffin-embedded brain tumors and 39 Glioblastoma multiforme (GBM) cell lines, we determined the frequency of five SEL1L single nucleotide genetic variants with regulatory and coding functions by a SNaPShot™ assay. We...
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