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Article

Epistasis Is a Major Determinant of the Additive Genetic Variance in Mimulus guttatus.

PLoS genetics - 1 May 2015

Monnahan Patrick J, Kelly John K

Abstract excerpt

The influence of genetic interactions (epistasis) on the genetic variance of quantitative traits is a major unresolved problem relevant to medical, agricultural, and evolutionary genetics. The additive genetic component is typically a high proportion of the total genetic variance in quantitative traits, despite that underlying genes must interact to determine phenotype. This study estimates direct and interaction...

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Identifiers

PMID: 25946702
DOI: 10.1371/journal.pgen.1005201
PMCID: PMC4422649

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