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Article

The association between 2D:4D ratio and cognitive empathy is contingent on a common polymorphism in the oxytocin receptor gene (OXTR rs53576).

Psychoneuroendocrinology - 1 Aug 2015

Weisman Omri, Pelphrey Kevin A, Leckman James F, Feldman Ruth, Lu Yunfeng, Chong Anne, Chen Ying, Monakhov Mikhail, Chew Soo Hong, Ebstein Richard P

Abstract excerpt

Both testosterone and oxytocin influence an individual's accuracy in inferring another's feelings and emotions. Fetal testosterone, and the second-to-forth digit ratio (2D:4D) as its proxy, plays a role in social cognitive development, often by attenuating socio-affective skill. Conversely, oxytocin generally facilitates socio-affiliative and empathic cognition and behavior. A common polymorphism in the oxytocin...

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Identifiers

PMID: 25935637
DOI: 10.1016/j.psyneuen.2015.04.007

Genes

OXTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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