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Article

The influence of rs53576 polymorphism in the oxytocin receptor (OXTR) gene on empathy in healthy adults by subtype and ethnicity: a systematic review and meta-analysis.

Reviews in the neurosciences - 27 Jan 2022

Chander Russell J, Mather Karen A, Cleary Rhiagh, Grainger Sarah A, Thalamuthu Anbupalam, Numbers Katya, Kochan Nicole A, Armstrong Nicola J, Brodaty Henry, Henry Julie D, Sachdev Perminder S

Abstract excerpt

Empathy is essential for navigating complex social environments. Prior work has shown associations between rs53576, a single nucleotide polymorphism (SNP) located in the oxytocin receptor gene (OXTR), and generalized empathy. We undertook a systematic review and meta-analysis to assess the effects of rs53576 on subdomains of empathy, specifically cognitive empathy (CE) and affective empathy (AE), in healthy...

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PMID: 33892530
DOI: 10.1515/revneuro-2021-0038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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