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Article

Multifunctional and stable bone mimic proteinaceous matrix for bone tissue engineering.

Biomaterials - 1 Jul 2015

Won Jong-Eun, Yun Ye-Rang, Jang Jun-Hyeog, Yang Sung-Hee, Kim Joong-Hyun, Chrzanowski Wojciech, Wall Ivan B, Knowles Jonathan C, Kim Hae-Won

Abstract excerpt

Biomaterial surface design with biomimetic proteins holds great promise for successful regeneration of tissues including bone. Here we report a novel proteinaceous hybrid matrix mimicking bone extracellular matrix that has multifunctional capacity to promote stem cell adhesion and osteogenesis with excellent stability. Osteocalcin-fibronectin fusion protein holding collagen binding domain was networked with...

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Identifiers

PMID: 25934278
DOI: 10.1016/j.biomaterials.2015.03.022

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