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Cas9-mediated targeting of viral RNA in eukaryotic cells

27 Apr 2015

Abstract excerpt

Clustered, regularly interspaced, short palindromic repeats-CRISPR associated (CRISPR-Cas) systems are prokaryotic RNA-directed endonuclease machineries that act as an adaptive immune system against foreign genetic elements. Using small CRISPR RNAs that provide specificity, Cas proteins recognize and degrade nucleic acids. Our previous work demonstrated that the Cas9 endonuclease from Francisella novicida...

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PMID: 25918406
DOI: 10.1073/pnas.1422340112

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