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Article

Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.

PloS one - 1 Jan 2015

Regland Björn, Forsmark Sara, Halaouate Lena, Matousek Michael, Peilot Birgitta, Zachrisson Olof, Gottfries Carl-Gerhard

Abstract excerpt

BACKGROUND: Patients with myalgic encephalomyelitis (ME, also called chronic fatigue syndrome) may respond most favorably to frequent vitamin B12 injections, in vital combination with oral folic acid. However, there is no established algorithm for individualized optimal dosages, and rate of improvement may differ considerably between responders. OBJECTIVE: To evaluate clinical data from patients with ME, with or...

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Identifiers

PMID: 25902009
DOI: 10.1371/journal.pone.0124648
PMCID: PMC4406448

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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