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Article

Endothelial progenitor cell phenotype and function are impaired in childhood-onset systemic lupus erythematosus.

Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2015

Mohan Smriti, Barsalou Julie, Bradley Timothy J, Slorach Cameron, Reynolds John A, Hasni Sarfaraz, Thompson Becky, Ng Lawrence, Levy Deborah, Silverman Earl, Kaplan Mariana J

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE) is characterized by increased cardiovascular risk in adult-onset and childhood-onset SLE. Type I interferons (IFNs) appear to play a prominent role in premature vascular damage in adult-onset SLE, at least in part, by inducing impairments in the phenotype and function of endothelial progenitor cells (EPCs), thereby hampering vascular repair. It is not clear whether...

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Identifiers

PMID: 25891295
DOI: 10.1002/art.39149
PMCID: PMC4519391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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