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Article

Evaluating BEST1 mutations in pluripotent stem cell-derived retinal pigment epithelial cells.

Methods in enzymology - 1 Jan 2021

Kittredge Alec, Zhang Yu, Yang Tingting

Abstract excerpt

Bestrophin-1 (BEST1) is a calcium-activated chloride channel (CaCC) predominantly expressed at the basolateral membrane of the retinal pigment epithelium (RPE). Over 250 mutations in the BEST1 gene have been documented to cause at least five retinal degenerative disorders, commonly termed bestrophinopathies, to which no treatment is currently available. Therefore, understanding the influences of BEST1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34120722
DOI: 10.1016/bs.mie.2021.01.004
PMCID: PMC9801436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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