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miR-424/322 is downregulated in the semen of patients with severe DNA damage and may regulate sperm DNA damage

14 Apr 2015

Abstract excerpt

Sperm DNA integrity is an essential factor for accurate transmission of genetic information. Human sperm DNA damage is a common cause of male infertility but the exact mechanism remains poorly understood. Considering the vital role of microRNA (miRNA) in multiple pathophysiological processes, we hypothesised that testicular miRNA is involved in sperm DNA damage during spermatogenesis. Infertile patients with high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25872494
DOI: 10.1071/rd15052

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