Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperhomocysteinemia and MTHFR polymorphisms as antenatal risk factors of white matter abnormalities in two cohorts of late preterm and full term newborns.

Oxidative medicine and cellular longevity - 1 Jan 2015

Marseglia Lucia M, Nicotera Antonio, Salpietro Vincenzo, Giaimo Elisa, Cardile Giovanna, Bonsignore Maria, Alibrandi Angela, Caccamo Daniela, Manti Sara, D'Angelo Gabriella, Mamì Carmelo, Di Rosa Gabriella

Abstract excerpt

Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Demography
Share to Hyperhomocysteinemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Linear Models

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Odds Ratio

Share to Premature Birth

Share to Prenatal Diagnosis

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 25829992
DOI: 10.1155/2015/543134
PMCID: PMC4338403

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperhomocysteinemia and MTHFR polymorphisms as antenatal risk factors of white matter abnormalities in two cohorts of late preterm and full term newborns.PMID 25829992Read ↗

Cerebral ultrasound abnormalities in offsprings of women with C677T homozygous mutation in the MTHFR gene: a prospective study.Semantic proximity Read ↗

Role of thrombophilic factors in full-term infants with neonatal encephalopathy.Semantic proximity Read ↗

Epigenetic Mechanisms Involved in the Effects of Maternal Hyperhomocysteinemia on the Functional State of Placenta and Nervous System Plasticity in the OffspringSemantic proximity Read ↗

Maternal mutation 677C > T in the methylenetetrahydrofolate reductase gene associated with severe brain injury in offspring.Semantic proximity Read ↗

Brain damage in preterm infants: etiological pathways.Semantic proximity Read ↗

Polymorphisms in vitamin B12 and folate metabolising genes and their association with adverse pregnancy outcome: secondary analysis of a population based case control study.Semantic proximity Read ↗

The impact of genetic and environmental factors on homocysteine levels in preterm neonates.Semantic proximity Read ↗

Genetic and epigenetic contributors and mimickers of phenotypic hypoxic-ischemic encephalopathy (HIE).Semantic proximity Read ↗

Low birthweight (LBW) and neonatal hyperbilirubinemia (NNH) in an Indian cohort: association of homocysteine, its metabolic pathway genes and micronutrients as risk factors.Semantic proximity Read ↗

Influence of early identification and therapy on long‐term outcomes in early‐onset MTHFR deficiencySemantic proximity Read ↗

Associative role of TYMS6bpdel polymorphism and resulting hyperhomocysteinemia in the pathogenesis of preterm delivery and associated complications: A study from Northeast India.Semantic proximity Read ↗

Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain DamageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.