Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia.

doi:10.1007/s00415-015-7718-3

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Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia.

Journal of neurology - 1 May 2015

Nibbeling Esther, Schaake Susen, Tijssen Marina A, Weissbach Anne, Groen Justus L, Altenmüller Eckart, Verbeek Dineke S, Lohmann Katja

Abstract excerpt

Musician's dystonia and writer's cramp are examples of task-specific dystonia. Recently, the arylsulfatase G (ARSG) locus was suggested to be associated with musician's dystonia and writer's cramp by a genome-wide association study. To test for the presence of causal variants, the entire coding region and exon-intron boundaries of ARSG were sequenced in DNA samples from 158 musician's dystonia patients which were...

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Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia.

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