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Article

FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors.

Pharmacogenomics - 1 Jan 2015

Montes Ariana, Perez-Pampin Eva, Joven Beatriz, Carreira Patricia, Fernández-Nebro Antonio, Del Carmen Ordóñez María, Navarro-Sarabia Federico, Moreira Virginia, Vasilopoulos Yiannis, Sarafidou Theologia, Caliz Rafael, Ferrer Miguel Angel, Cañete Juan D, de la Serna Arturo R, Magallares Berta, Narváez Javier, Gómez-Reino Juan J, Gonzalez Antonio

Abstract excerpt

OBJECTIVES: Reproducible association of a functional polymorphism in FCGR2A with response to a TNF inhibitor (TNFi) in patients with rheumatoid arthritis (RA) led us to explore other FcγR functional polymorphisms. METHODS: Functional polymorphisms FCGR3A F158V, FCGR2B I223T and promoter VNTR in FCGRT were analyzed in up to 429 patients with RA. Response to TNFi was recorded during standard care at 3, 6 and 12...

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Topics

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Share to Arthritis, Rheumatoid
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Receptors, Fc

Share to Receptors, IgG

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 25823782
DOI: 10.2217/pgs.14.175

Genes

TNF
FCGRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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