Article
Antithrombin III deficiency in Indian patients with deep vein thrombosis: identification of first India based AT variants including a novel point mutation (T280A) that leads to aggregation.
PloS one - 1 Jan 2015
Bhakuni Teena, Sharma Amit, Rashid Qudsia, Kapil Charu, Saxena Renu, Mahapatra Manoranjan, Jairajpuri Mohamad Aman
Abstract excerpt
Antithrombin III (AT) is the main inhibitor of blood coagulation proteases like thrombin and factor Xa. In this study we report the identification and characterization of several variants of AT for the first time in Indian population. We screened 1950 deep vein thrombosis (DVT) patients for AT activity and antigen levels. DNA sequencing was further carried out in patients with low AT activity and/or antigen...
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