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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids

23 Mar 2015

Abstract excerpt

Flavonoids were found previously to modulate efficiency of synthesis of glycosaminoglycans (GAGs), compounds which are accumulated in cells of patients suffering from mucopolysaccharidoses (MPSs). The aim of this work was to determine effects of different flavonoids (genistein, kaempferol, daidzein) used alone or in combinations, on expression of genes coding for proteins involved in GAG metabolism. Analyses with...

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PMID: 25797591
DOI: 10.1038/srep09378

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