Successful treatment of refractory cold hemagglutinemia in MYD88 L265P mutation-negative Waldenström's macroglobulinemia with bortezomib.

doi:10.1007/s12185-015-1775-3

Article

Successful treatment of refractory cold hemagglutinemia in MYD88 L265P mutation-negative Waldenström's macroglobulinemia with bortezomib.

International journal of hematology - 1 Aug 2015

Izumi Mayuko, Tsunemine Hiroko, Suzuki Yasuhiro, Tomita Akihiro, Kusumoto Toshiko, Kodaka Taiichi, Itoh Kiminari, Takahashi Takayuki

Abstract excerpt

We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9 g/dL, serum IgM concentration of 1904 mg/dL, and a titer of cold hemagglutinin of over ×8192....

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