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Homologous and Heterologous Protection of Nonhuman Primates by Ebola and Sudan Virus-Like Particles

20 Mar 2015

Abstract excerpt

Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored approaches and virus-like particles (VLPs) have shown efficacy in nonhuman primates. Previous studies have shown protection of cynomolgus macaques against homologous infection for Ebola virus (EBOV) and Marburg virus (MARV) following a three-dose vaccine...

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PMID: 25793502
DOI: 10.1371/journal.pone.0118881

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