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Article

REV3L, a Promising Target in Regulating the Chemosensitivity of Cervical Cancer Cells

17 Mar 2015

Abstract excerpt

REV3L, the catalytic subunit of DNA Polymerase ζ (Polζ), plays a significant role in the DNA damage tolerance mechanism of translesion synthesis (TLS). The role of REV3L in chemosensitivity of cervical cancer needs exploration. In the present study, we evaluated the expression of the Polζ protein in paraffin-embedded tissues using immunohistochemistry and found that the expression of Polζ in cervical cancer...

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PMID: 25781640
DOI: 10.1371/journal.pone.0120334

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