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Article

Estimating the proportion of true null hypotheses when the statistics are discrete.

Bioinformatics (Oxford, England) - 15 Jul 2015

Dialsingh Isaac, Austin Stefanie R, Altman Naomi S

Abstract excerpt

MOTIVATION: In high-dimensional testing problems π0, the proportion of null hypotheses that are true is an important parameter. For discrete test statistics, the P values come from a discrete distribution with finite support and the null distribution may depend on an ancillary statistic such as a table margin that varies among the test statistics. Methods for estimating π0 developed for continuous test...

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Identifiers

PMID: 25735771
DOI: 10.1093/bioinformatics/btv104
PMCID: PMC4495288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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