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Article

Heterozygote advantage at MHC DRB may influence response to infectious disease epizootics.

Molecular ecology - 1 Apr 2015

Osborne Amy J, Pearson John, Negro Sandra S, Chilvers B Louise, Kennedy Martin A, Gemmell Neil J

Abstract excerpt

The effect of MHC polymorphism on individual fitness variation in the wild remains equivocal; however, much evidence suggests that heterozygote advantage is a major determinant. To understand the contribution of MHC polymorphism to individual disease resistance or susceptibility in natural populations, we investigated two MHC class II B loci, DQB and DRB, in the New Zealand sea lion (NZSL, Phocarctos hookeri)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25728376
DOI: 10.1111/mec.13128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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