Article
[Clinical associations of genetic variants of interleukins with the formation of chronic lympholeukemia in elderly patients].
Klinicheskaia meditsina - 1 Jan 2013
Sirotina S S, Tikunova T S, Proshchaev K I, Efremova O A, Churnosov M I, Sirotin A A, Evdokimov V I, Poltoratskii A N, Smagina M V
Abstract excerpt
We investigated association of polymorphisms of interleukin IA (IL-1A), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin-8 (1L-8) genes in elderly patients with predisposition to the development of chronic lym,nphocytic leukemia (CLL). Risk factor of chronic lymphocytic leukemia is a genetic variant -590T IL-4 (OR = 1,45) and protective factor -590S IL-4 (OR = 0,68). Genetic markers -590T IL-4 (OR = 2,46),...
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