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Article

A single natural nucleotide mutation alters bacterial pathogen host tropism.

Nature genetics - 1 Apr 2015

Viana David, Comos María, McAdam Paul R, Ward Melissa J, Selva Laura, Guinane Caitriona M, González-Muñoz Beatriz M, Tristan Anne, Foster Simon J, Fitzgerald J Ross, Penadés José R

Abstract excerpt

The capacity of microbial pathogens to alter their host tropism leading to epidemics in distinct host species populations is a global public and veterinary health concern. To investigate the molecular basis of a bacterial host-switching event in a tractable host species, we traced the evolutionary trajectory of the common rabbit clone of Staphylococcus aureus. We report that it evolved through a likely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25685890
DOI: 10.1038/ng.3219
PMCID: PMC4824278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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