Article
A screen of a large Czech cohort of oligodontia patients implicates a novel mutation in the PAX9 gene.
European journal of oral sciences - 1 Apr 2015
Šerý Omar, Bonczek Ondřej, Hloušková Alena, Černochová Pavlína, Vaněk Jiří, Míšek Ivan, Krejčí Přemysl, Izakovičová Hollá Lydie
Abstract excerpt
Tooth agenesis is one of the most common developmental anomalies in humans. To date, many mutations involving paired box 9 (PAX9), msh homeobox 1 (MSX1), and axin 2 (AXIN2) genes have been identified. The aim of the present study was to perform screening for mutations and/or polymorphisms using the capillary sequencing method in the critical regions of PAX9 and MSX1 genes in a group of 270 individuals with tooth...
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