A differential susceptibility analysis reveals the "who and how" about adolescents' responses to preventive interventions: tests of first- and second-generation Gene × Intervention hypotheses.

Abstract excerpt

This study was designed to investigate a genetic moderation effect of dopamine receptor 4 gene (DRD4) alleles that have seven or more repeats (long alleles) on an intervention to deter drug use among rural African American adolescents in high-risk families. Adolescents (N = 291, M age = 17) were assigned randomly to the Adults in the Making (AIM) program or to a control condition and were followed for 27.5...

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